Ana Sayfa | Dergi Hakkında | Yayın Kurulu | Bilimsel Danışma Kurulu | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | İletişim  
2017, Cilt 31, Sayı 3, Sayfa(lar) 135-144   
Gökhan AYKUN1, Mükremin ER2, Ayşegül KARALEZLİ3, H.Canan HASANOĞLU3
1Tokat Medical Park Hastanesi, Göğüs Hastalıkları Bölümü, Tokat, Türkiye
2Ankara Atatürk Eğitim ve Araştırma Hastanesi, Göğüs Hastalıkları Bölümü, Ankara, Türkiye
3Yıldırım Beyazıt Üniversitesi Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Ankara, Türkiye
Keywords: Pulmonary embolism, pulmonary CT angiography, r-TPA

Aim: Benefit of thrombolytic therapy for the patients with pulmonary embolism is thought to be in only the first few days and it’s considered that after the first week anticoagulation therapy has similar rates of resolution. The purpose of the study is to investigate the effect of thrombolytic therapy on the patient's clinical parameters and Pulmonary Artery CT Obstruction Index opening rates on the tenth day.

Material and Methods: In this study, 28 pulmonary embolism cases were investigated. Taken in to consideration clinical, radiographic, echocardiographic, biochemical findings, and contraindications to thrombolytic therapy, 15 patients enrolled to the thrombolytic therapy group (group 1) and the remaining 13 patients were included in the conventional therapy (group 2).Patients given thrombolytic therapy(r-TPA) in the first 14 days after pulmonary embolism was planned as group 3 and treated with anticoagulants only as group 4. Pulmonary CT angiography, transthoracic echocardiography (ECHO), arterial blood gasses were studied on admission and tenth day. PACTOI was calculated from pulmonary CT angiography.

Results: Differences were insignificant between the groups for the initial criteria. Opening rate on the tenth day was 52.8%±25.5 in group 1 and 42.5%±20.0 in group 2. In patients of group 3 opening rate was 58.4%±24.5 on the tenth day, whereas in group 4 it was 42.2%±22.2. Significant improvements on PO2, SaO2 and PAP was seen in group 3 patients at the tenth day when compared with group 4 (p<0.05).

Conclusion: As a conclusion it is shown that patients receiving thrombolytic therapy had better PACTOI and ABG and ECHO findings at the tenth day.