Ana Sayfa | Dergi Hakkında | Yayın Kurulu | Bilimsel Danışma Kurulu | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | İletişim  
2019, Cilt 33, Sayı 3, Sayfa(lar) 177-187   
SARCOIDOSIS: 20 YEARS OF EXPERIENCE IN DIAGNOSIS, TREATMENT AND FOLLOW-UP
Eylem TUNÇAY1, Murat YALÇINSOY2, Sinem GÜNGÖR1, Pakize SUCU3, Sümeyye APLARSLAN BEKİR1, Fatma TOKGÖZ AKYIL4, Dilek YAVUZ3, Bülent ALTINSOY5, Cüneyt SALTÜRK6, Zeynep Ferhan ÖZŞEKER7
1Sağlık Bilimleri Üniversitesi Süreyyapaşa Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi, Göğüs Hastalıkları, İstanbul, Türkiye
2İnönü Üniversitesi Tıp Fakültesi, Göğüs Hastalıkları, Malatya, Türkiye
3Arnavutköy Devlet Hastanesi, Göğüs Hastalıkları, İstanbul, Türkiye
4Çanakkale Devlet Hastanesi, Göğüs Hastalıkları, Çanakkale, Türkiye
5Zonguldak Bülent Ecevit Üniversitesi Tıp Fakültesi, Göğüs Hastalıkları, Zonguldak, Türkiye
6Yeni Yüzyıl Üniversitesi Tıp Fakültesi, Göğüs Hastalıkları, İstanbul, Türkiye
7İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Göğüs Hastalıkları, İstanbul, Türkiye
Keywords: Sarcoidosis, diagnosis, clinic, follow-up

Aim: Sarcoidosis is a granulomatous disease with unknown origin. Long and short-term follow-up and diagnosis of sarcoidosis are challenging in daily practice and require experience. In our study, the diagnosis, treatment and follow-up results of patients with sarcoidosis followed for 20 years were examined.

Material and method: Sarcoidosis patients followed in tertiary chest diseases clinic between 1994-2014 were evaluated. Demographic features, referral complaints, tuberculin skin test, biochemical parameters, radiological features, PFT and DLCO measurements, diagnosis, treatment, long-short term follow-up results were evaluated.

Results: Of the 338 patients, 241 (71.3%) were female. The mean age at the time of diagnosis was 42.6±11.6 (17-75) years. While 48 (14.2%) patients were diagnosed based on clinical, laboratory and radiological findings, invasive procedures were performed to the rest. The most commonly used invasive methods were transbronchial biopsy (42.6%), mediastinoscopy or transbronchial biopsy (40.8% and 13.9%, respectively) and bronchial mucosal biopsy (forceps biopsy) (35.2%). 262 (75.6%) of the patients were followed without treatment and 76 (22.4%) were treated in different periods. 22 (6.2%) patients had relapse in the postdiagnosis period. The patients followed-up without and with treatment, relapse rates were 3 patients (2.5%) and 19 patients (42%), respectively (p <0.01).

Conclusion: Sarcoidosis affects different organs and has different clinical presentations; besides spontaneous remission is occurred in the most of patient. However, mortality and morbidity are high in advanced disease. As determined in present study frequency of relapse is high in patients with advanced stage. Early diagnosis of sarcoidosis, close follow-up of patients with advanced disease in terms of relapse, mortality and morbidity, are important in clinical practice.